In Spider: The Video Game you control a spider that has been implanted with a neural transmitter port, cybernetic legs, and weapon accessories. You begin at a sector map which functions as a blueprint of the research laboratory which you must explore. In order to clear a level, you must collect a required number of microchips. You must also find exits in each area in order to advance to the next level. The spider is always equipped with a Slasher leg and webbing, and he is capable of enhancing his fighting ability with weapons by collecting power-ups. The weapons include homing missiles, flame throwers, boomerangs, and electro-beams. You'll need these munitions to defend yourself against other spiders, cyber-rats, toxic green frogs, and other laboratory pests in this 3-D side-scrolling platform contest.